New York City certainly has seem a dramatic transformation over the past 400 years. Almost nothing from the time my 10th great-grandfather, Daniel Tourneur, lived in Harlem in the 1660s remains, except what is written in the records.
From the book, "New Harlem past and present; the story of an amazing civic wrong, now at last to be righted", we read "On lot g stood the house of Daniel Tourneur". The map provided in the book shows us exactly where it was located, and other properties Daniel owned. A detailed view of the same map is shown below, with lot g outlined in red.
We can learn more about Daniel's land holdings in 1670, on page 63:
This satellite image from Google Maps shows the approximate location of Daniel Tourneur's house in Harlem, possibly in the middle of present day 124th Street between 1st Avenue and 2nd Avenue in Harlem.
You can also view the location from street level view on Google Maps here. Click on the image to look around or navigate down the street.
He also appears to have owned Lot 7 of Upper Horn's Hook, (p. 101-102 of New Harlem Past and Present).
Source:
New Harlem past and present; the story of an amazing civic wrong, now at last to be righted, by Carl H. Pierce, W.P. Toler, and H.D. Nutting, 1903